I'm currently playing Clarinet I on a production of The Sound Of Music, and thus am logging a lot more clarinet time than is normal for me these days. With the way that a Legere reed feels on my baritone, I can only imagine how much abuse my lips would take with the same on the clarinet.
I really wanted to like the Legere reeds, and even went so far as to purchase a significant spread of Legere reeds for same, bracketing my normal Vandorns on both sides (just to be safe). What I found was:
1) The reeds softened up after a short period of playing, so much so that I could not rely on them to be consistent.
2) The edges were hard on my lips. This combined with the lack of texture (which made it hard for me to keep a consistent position on the reed) was the real killer for the deal.
Over the years, I've tried most of the synthetic reed products as they became available, but in no case was I as satisfied with them as with plain ol' cane. But, that's why it's still a free world.
And, I lasted about thirty seconds with a synthetic bassoon reed. Horrid tone, same mouth feel problems.